Overview
AOD-9604 (Advanced Obesity Drug 9604) is a modified fragment of human growth hormone corresponding to amino acids 176-191 of the C-terminal region. The fragment was isolated by researchers investigating which portion of the GH molecule was responsible for lipolytic activity, separate from the anabolic and diabetogenic effects associated with full-length GH. By isolating this fragment, AOD-9604 retains the proposed fat-metabolizing properties while being structurally unable to activate the IGF-1 or insulin signaling pathways associated with full-length GH administration.
AOD-9604 was notably designated as a Generally Recognized As Safe (GRAS) food ingredient by the FDA in 2014 following extensive safety submissions, reflecting its favorable safety profile relative to full-length GH. It has been investigated in models of obesity, lipid metabolism, and cartilage repair, and was the subject of multiple Phase 2 and Phase 3 clinical trials for obesity management.
Mechanism of Research Interest
- Stimulation of lipolysis (fat breakdown) in adipocytes independent of IGF-1 production
- Inhibition of lipogenesis — reducing new fat storage in adipose tissue
- Proposed interaction with β3-adrenergic receptors on fat cells, bypassing the growth-promoting pathway of full-length GH
- No significant effect on blood glucose or insulin sensitivity at research doses
- Potential modulation of cartilage and bone metabolism via mechanisms separate from IGF-1
Specifications
| Full Name | AOD-9604 (GH Fragment 176-191) |
| Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (cyclized) |
| Formula | C₇₈H₁₂₃N₂₃O₂₃S₂ |
| MW | 1,815.1 Da |
| CAS | 221231-10-3 |
| Purity | ≥98% HPLC |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Storage Lyophilized | −20°C |
| Storage Reconstituted | 2–8°C, use within 4–6 weeks |
| Solubility | Sterile or bacteriostatic water |
Reconstitution
Reconstitution Protocol
Reconstitute with sterile water or bacteriostatic water. Add solvent slowly along the inside wall of the vial and gently swirl — do not vortex. Store reconstituted at 2–8°C and use within 4–6 weeks. Do not freeze reconstituted solution.
Quality & Purity
Every batch of AOD-9604 undergoes third-party HPLC testing to verify ≥98% purity. COA included with every order.
Research Use Only. AOD-9604 supplied by Trusty Peptide is intended strictly for laboratory and in vitro research purposes. It is not approved for human or veterinary use, and is not a medicine, drug, or nutritional supplement. By purchasing you confirm you are a qualified researcher using this compound for legitimate scientific research only.