Overview
The CJC-1295 / Ipamorelin blend combines two complementary growth hormone axis peptides into a single research preparation. CJC-1295 (also known as modified GRF 1-29, or Mod GRF 1-29) is a truncated analog of growth hormone-releasing hormone (GHRH) consisting of the first 29 amino acids with four substitution modifications that confer DPP-IV resistance and increased receptor binding affinity.
Ipamorelin is a selective growth hormone secretagogue receptor (GHSR) agonist — a pentapeptide GHRP — that stimulates GH release via a distinct receptor pathway from GHRH. When combined, CJC-1295 and ipamorelin have been observed in preclinical research to produce synergistic GH release that is greater than either peptide alone. The blend is formulated at an equimolar ratio and is a popular subject in growth hormone axis research.
Mechanism of Research Interest
- CJC-1295 binds pituitary GHRH receptors (GHRHr), triggering cAMP-mediated GH synthesis and pulsatile release from somatotrophs
- Ipamorelin binds growth hormone secretagogue receptors (GHSR-1a), increasing GH release via a distinct intracellular Ca²⁺ pathway
- Co-administration amplifies GH pulse amplitude while preserving physiological pulsatility patterns
- Ipamorelin demonstrates high GH selectivity with minimal prolactin, cortisol, or ACTH stimulation compared to earlier GHRPs
- The combination may enhance IGF-1 response relative to either agent alone
Technical Specifications
| Components | CJC-1295 (Mod GRF 1-29) + Ipamorelin (50:50) |
| CJC-1295 Class | GHRH analog (DPP-IV resistant) |
| Ipamorelin Class | GHRP / GHSR agonist |
| Ratio | Equimolar blend |
| Purity (each component) | ≥98% (HPLC verified) |
| Form | Lyophilized powder (combined) |
| Appearance | White to off-white powder |
| Storage (lyophilized) | −20°C protected from light |
| Storage (reconstituted) | 2–8°C, use within 4 weeks |
| Solubility | Sterile water or bacteriostatic water |
Reconstitute with sterile water or bacteriostatic water. Both components are water-soluble and dissolve readily together. Add solvent slowly along the inside wall of the vial and gently swirl — do not vortex. Store reconstituted solution at 2–8°C and use within 4 weeks. Do not freeze reconstituted solution.
Quality Assurance
Every batch of CJC-1295 / Ipamorelin Blend supplied by Trusty Peptide undergoes third-party HPLC testing to verify purity of ≥98% for each component. A Certificate of Analysis (COA) is included with every order.
Research Use Only. This product is intended for laboratory and research purposes only. Not for human or veterinary use. By purchasing you confirm you are a qualified researcher using this product for legitimate scientific research purposes only.